主要研究方向：
DNA存储和计算、生物信息和DNA测序技术等
研究成果概况：
张成现为北京大学计算机学院，副研究员，博士生导师。主要围绕生物计算和分子先进制造领域：DNA分子信息处理技术开展研究。以第一或通讯作者身份在Nature，Nature Communications，Science Advances，JACS，Angew. Chem. Int. Ed.，IEEE TNB，中国科学，科学通报等期刊发表论文40余篇。作为主持人承担国家省部级项目多个，包括：国家重点研发计划项目、军委信息装备专项、重点研发“政府间”合作专项、国家自然科学基金、教育部联合基金和北京市联合专项等。先后获教育部自然科学奖一等奖（2012）/二等奖（2023）；入选中科院创新交叉团队（2020），及中国智能计算科技创新人物（2022）。担任中国计算机，自动化，人工智能等多个学会的生物信息专委会委员。
代表性论文：（*通讯作者）
1.Cheng Zhang*, Ranfeng Wu, Fajia Sun, Yisheng Lin, Yuan Liang, Jiongjiong Teng, Na Liu, Qi Ouyang*, Long Qian*, Hao Yan*. Parallel molecular data storage by printing epigenetic bits on DNA. Nature, 634, 824-832, 2024.
2. Liang Yuan, Qie Yunkai, Jing Yang, Wu Ranfeng, Cui Shuang, Zhao Yuliang, Greg J. Anderson, Guangjun Nie, Suping Li*, Cheng Zhang*. Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction. Nature Communications, 14, 4898, 2023.
3. Jing Yang, Yuan Liang, Xiang Li, Yongpeng Zhang, Long Qian*, Yonggang Ke*, Cheng Zhang*, Spatially Programmable Enzymatic Nanorobot Arm to Modulate Anisotropic Gold Nanoparticle Assembly. Angewandte Chemie International Edition, 62, e202308797, 2023.
4. Cheng Zhang*, Xueying Ma, Xuedong Zheng, Yonggang Ke, Kuiting Chen, Dongsheng Liu, Zuhong Lu, Jing Yang*, Hao Yan*, Programmable Allosteric DNA Regulations for Molecular Networks and Nanomachines. Science advances, 8, eabl4589, 2022.
5. Cheng Zhang*, Zhiyu Wang, Yan Liu, Jing Yang, Xinxin Zhang, Linqiang Pan, Yonggang Ke*, Hao Yan*. Nicking Assisted Reactant Recycle to Implement Entropy-Driven DNA Circuit. J. Am. Chem. Soc., 141, 17189-17197, 2019.
6. Ranfeng Wu, Yongpeng Zhang, Jiongjiong Teng, Qiang Zhang, Cheng Zhang*. Molecular Circuit-Controlled Nanoparticle Folders for Programmable DNA Information Access. ACS nano, 19(19): 6918-6928, 2025.
7. Zhang Yongpeng, Chen Yiming, Liu Xuan, Ling Qian, Wu Ranfeng, Yang Jing*, Cheng Zhang*, Programmable Primer Switching for Regulating Enzymatic DNA Circuits. ACS nano, 18, 5089−5100, 2024.
8. Ranfeng Wu, Yiming Chen, Yongpeng Zhang, Rongming Liu, Qiang Zhang*, Cheng Zhang*, Catalytic Gold Nanoparticle Assembly Programmed by DNAzyme Circuits. Small, 2307107, 2024.
9. Jing Yang, Juan Wang, Xuan Liu, Yiming Chen, Yuan Liang, Qi Wang, Shuoxing Jiang*, Cheng Zhang*. Translocation of Proteins through Solid-State Nanopores Using DNA Polyhedral Carriers. Small, 2303715, 2023.
10. Jing Yang, Ranfeng Wu, Zhiyu Wang, Linqiang Pan, Qiang Zhang, Zuhong Lu*, Cheng Zhang*, Entropy-Driven DNA Logic Circuits Regulated by DNAzyme. Nucleic Acids Research, 46, 8532-8541, 2018.
